Platelet Surface Engineering

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Researchers report the development of platelet membrane (PM)-coated core-shell nanovehicle (designated PM-NV) for targeting and sequential and site-specific delivery of the small molecular drug.

In order to prevent thrombogenesis and maintain the integrity of blood circulation, platelets, which are microscopic blood cells, target the sites of vascular injury. Recently, cell-based systems, such as erythrocytes, bacterial ghosts, and genetically modified stem cells, have become popular as biological drug carriers. In order to increase the effectiveness of treatment, modified platelets and platelet membrane are frequently employed to coat nanoparticles containing medications.

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